Chromium Picolinate is derived from picolinic acid and chromium and is sold as a chemical compound as a nutritional supplement deemed to combat chromium deficiencies. Chromium Picolinate has shown some positive effects in treatments of atypical depression, particularly instances where carbohydrate cravings were significantly reduced made the weight loss community become interested. Currently chromium picolinate is being marketed as a supplement supposed to help body builders and athletes to develop muscles, burning excess fat, a claim which could not be verified but is persistent. While chromium is essential in the insulin metabolism, assisting in stabilizing the body’s sugar levels in the blood, the actual effect of chromium picolinate supplement in muscle building humans requires further research. In body building circles, chromium picolinate is deemed an essential part of a proper diet.

PEA (Phenylethylamine), which is also known as Beta-Phenylethylamine, is a supplement, which favors aggression and is supposed to raise mental alertness, focus, and ability to concentrate. It is believed to also promote energy. In clinical trials it has been observed that infusion of Beta-Phenylethylamine raises the extracellular dopamine count, furthermore inhibiting the dopamine transmitter DA neuron firings. An additional activity is seen through the Beta-Phenylethylamine modulation of noradrenergic transmissions. It is viewed as a stimulant, but the lack or disturbed amounts of PEA have been observed in people with attention deficit and the hyperactivity disorders, people suffering from depression, schizophrenia, migraine and phenylketonuria. The obvious antidepressant qualities are paired with the increased wakefulness, which may lead to difficulty falling asleep, but improve motivation when exercising or training.

Synephrine, More commonly called "bitter orange" or Citrus Aurantium, which is taken from unripe oranges. Research shows that citrus aurantium can increase the metabolic rate without affecting heart rate or blood pressure, breaks down fat, burns calories and may act as an appetite suppressant.

Vitamin B12- Also called Riboflavin, B2 is a water absorbed vitamin of which the body must replenish its supplies each day as it cannot be stored. It is necessary for the production of red blood cells and, like the other B vitamins, it works at supporting it supports energy production by helping in the metabolism of various foods.B2 is required for healthy skin as well as hair growth, the nails and has a role in regulating the activity of the thyroid gland. It is also necessary in order that the body can process amino acids found in proteins and fats and to activate vitamin B6 and folic acid.