Bioperine is a convenient and concentrated form of black pepper’s ingredient called piperine. Bioperine enhances bioavailability and absorption. Bioperine is a safe and pure nutritional piperine supplement. This is an alkaloid that is available from the fruits. Piperine is responsible for the ability of pepper to enhance the nutrients bioavailability. 95% piperine is present in Bioperine. Black pepper was popular as it was the most desired spice. The black pepper was useful in ayurvedic medicine as it increased the food digestibility. The pepper consumption shows positive indication by generating internal heat. The nutritional status is based on a person and his eating style. Bioperine enhances the heat production in the body and this result in food digestion and eventually the energy is used. Bioperine facilitates the bioavailability of nutrients in a broad range. Bioperine is considered to be a thermogenic local agent as it increases the thermogenic reactions. Bioperine is an apposite nutritional supplement identical to pepper that is to food.

Caffeine is a central nervous system stimulant that temporarily wards off drowsiness and boosts alertness and energy.

Synephrine, More commonly called "bitter orange" or Citrus Aurantium, which is taken from unripe oranges. Research shows that citrus aurantium can increase the metabolic rate without affecting heart rate or blood pressure, breaks down fat, burns calories and may act as an appetite suppressant.

Synthetic Guggulsterones are derived from a herb, commiphora mukul, which has been proven to restore lagging metabolic rate brought about by dietary caloric deficiency, such as a diet low in carbohydrates. Though it has cholesterol lowering ability, it is also known as powerful weight loss agent due to the increased conversion of the inactive thyroid hormone T4 into its active part T3 in the liver. Furthermore, Guggulsterones are also known to stimulate the thyroid directly by enhancing TSH (Thyroid Stimulating Hormone) production. This is especially true for two specific guggulsterones codenamed Z and E.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.